The phase 1 trial enrolled 115 people to test single and multiple ascending doses of the oral, once-daily TREM2 agonist VG-3927. Vigil included an elderly cohort and a single dose arm of 11 ...
Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual ...
Research from VIB-UGent identifies lipid-associated macrophages and LAM-like Kupffer cells as critical for liver repair. The study reveals TREM2's role in clearing damaged cells and promoting recovery ...
The second reason is that, despite the fact that it recently reported positive results from its phase 1 study using small molecule TREM2 agonist VG-3927, a competitor using a drug with the same ...
“As the first and only Phase 2-ready oral, once-daily small molecule TREM2 agonist, VG-3927 is designed to provide a differentiated profile that can go beyond targeting amyloid plaques to ...
PK and sTREM2 reduction observed in the Alzheimer’s cohort was consistent with healthy volunteers and similar across evaluated TREM2 and ApoE genetic variants supporting development in Alzheimer ...
According to the company, the study led to no serious adverse events related to VG-3927, a once-daily small molecule that targets the human triggering receptor expressed on myeloid cells 2 (TREM2 ...
"This revealed that expression of the Trem2 gene is essential in at least one of these populations (LAMs or LAM-like KCs) for the efficient clearance of dying and injured liver cells". In other ...
"This revealed that expression of the Trem2 gene is essential in at least one of these populations (LAMs or LAM-like KCs) for the efficient clearance of dying and injured liver cells". In other ...
Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing ...
Iluzanebart, Vigil's lead clinical candidate, is a fully human monoclonal antibody agonist targeting human triggering receptor expressed on myeloid cells 2 (TREM2) in people with adult-onset ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results