USA Today's NFL experts make their picks for a Week 11 showdown between the Arizona Cardinals and San Francisco 49ers

This article was originally published on www.si.com/nfl/49ers/onsi as Kyle Shanahan Sounds Off on the Matchup with the Arizona Cardinals. It’s never wise for a team to overlook an opponent, no matter how lowly they may be performing. That’s especially the case when it’s a divisional matchup

ESPN and NFL Media are both reporting the Cardinals are likely to part ways with quarterback Kyler Murray, as Jacoby Bissett takes over as starter.

In Week 11, the Arizona Cardinals host the San Francisco 49ers, but they will be without wide receiver Marvin Harrison Jr., who will miss the game after undergoing surgery for appendicitis.

In Sunday’s game against the Arizona Cardinals, former USC quarterback Sam Darnold led the Seattle Seahawks to a dominant win. However, Darnold was not the only Trojan QB to play in the game. With Arizona getting blown out late in the game, the Cardinals brought in former USC quarterback Kedon Slovis for his NFL debut.

GLENDALE, Ariz. – Linebacker Tatum Bethune quickly nixed any comparisons between Arizona Cardinals tight end Trey McBride and 49ers counterpart George Kittle. “Nah, nah, not at all. George, nobody is similar to George,” Bethune said. “George is a unicorn.”

Injuries and veteran leadership clash as key defenders aim to dominate this crucial NFC West showdown. Keep your eyes on these defensive standouts.

San Francisco 49ers team reporter Briana Jeannel addresses fans’ biggest questions ahead of Week 11 vs. the Arizona Cardinals.