Fifth-round pick Marques Sigle could be called on to fill the starting safety spot for the San Francisco 49ers amid free agency and injury losses.

San Francisco 49ers player Deommodore Lenoir was arrested in Los Angeles on a charge of obstructing law enforcement and later released Friday, police said.

The 49ers are still co-favorites to win the NFC West, and betting against Kyle Shanahan has been a losing effort for the majority of his NFL career.

The San Francisco 49ers have eight huge home games at Santa Clara, CA's Levi's Stadium in 2025. Here's how to see Brock Purdy, Christian McCaffrey and the rest of Kyle Shanahan's stacked squad live.

The San Francisco 49ers have the No. 11 pick in the NFL draft. Here are the 49ers 2025 NFL Draft picks, with grades and analysis.

San Francisco 49ers draft picks, grades: NFL draft order, mock drafts, rumors as Mykel Williams taken 11th Where the San Francisco 49ers stand in the 2025 NFL Draft ...

The San Francisco 49ers were approaching the 2025 NFL draft in a position to improve. After a 6-11 season, there has been plenty of talk about the 49ers focusing on additions to their defensive ...

49ers trade Deebo Samuel to Commanders for a fifth-round pick. Here's why San Francisco made this shocking move.

The San Francisco 49ers’ search to replace recently-fired defensive coordinator Nick Sorensen has been somewhat confusing. Could they now turn to Pete Carroll?

Fox analyst Mark Sanchez compared a Los Angeles Rams catch to Willie Mays during Sunday's San Francisco 49ers game, pissing off many Bay Area fans.