GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with ≈800 members. GPCRs regulate nearly every aspect of human ...
A group of international researchers reports the availability of a new “map”’ of every gene, protein, and metabolic pathway required for a cell to efficiently secrete recombinant proteins. The team, ...
A recent study published in the journal Frontiers in Endocrinology investigated the role of the short-chain dehydrogenase/reductase 42E member 1 (SDR42E1) enzyme in regulating sterol metabolism and ...
1 Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson’s disease protein
Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...
Various signaling pathways guide the organization of cells and tissues in the body. Among these is the Bone Morphogenetic Protein (BMP) pathway, which plays a vital role in instructing early ...
1 Department of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, Naples, Italy 2 Department of Physiology, Development and Neuroscience, University of Cambridge, ...
Summary: Researchers have identified a protein, TMEM16F, that appears to aid the spread of Parkinson’s pathology in the brain. They found that a mutation in this protein promotes the secretion of a ...
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