At least 16 people were killed in weather-related fatalities this week, including tornadoes that destroyed entire neighborhoods.

A storm system sweeping over large areas of the U.S. South and Midwest resulted in at least 16 weather-related deaths by early Sunday, with overnight tornado and flash flood warnings setting up more severe weather that forecasters say could cause rising waterways for days to come.

Another round of torrential rain and flash flooding came Saturday for parts of the South and Midwest already heavily waterlogged by days of severe storms that also spawned deadly tornadoes. Forecasters warned that rivers in some places would continue to rise for days.