DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...

Perturbations of endoplasmic reticulum function from many causes activate a signalling pathway referred to as the UPR 15, resulting in transcriptional activation of genes whose products promote ...

Max Planck Institute of Molecular Cell Biology and Genetics led a study showing that directional, non-vesicular lipid transport drives fast, species-selective lipid sorting, outpacing slower, less ...

Scientists have discovered that these cells' endoplasmic reticulum (ER) changes its shape in different ways. When the gap curves outward (convex), the ER forms tube-like shapes, but when the gap ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes ...

Further, the interplay between endoplasmic reticulum stress and oxidative stress was investigated in vitro using a human leukemic monocytic cell line under a hyperglycemic environment and examined the ...

Cigdem Cicek, Pelin Telkoparan-Akillilar, Semra Sertyel, Cumhur Bilgi, Osman Denizhan Ozgun, Investigation of endoplasmic reticulum stress-regulated chaperones as biomarkers in idiopathic ...

Fat-induced stress and metabolic overload of the endoplasmic reticulum can alter its function, triggering chronic inflammation, which plays an important role in the development of atherosclerosis.

The endoplasmic reticulum functions as a reservoir for calcium and carbohydrates and also serves as the site for the synthesis of various hormones. Cells adjust the expansion and networking of ...