A protein known as granzyme K was recently shown to be a driver of inflammation by activating the complement system in human tissue, a discovery that could reshape the treatment of many rheumatic ...

Blood samples from long COVID patients showed changes to blood serum proteins at 6 months that indicated activation of the immune system's complement cascade, altered coagulation, and tissue ...

Study findings PASC symptoms were observed in 40 patients at six months, with changes to blood serum proteins indicating activation of the complement cascade, altered coagulation, and tissue injury.

Consequently, the complement cascade up to CD5 remains active, and C3 continues to coat the red blood cells.

Additionally, it enhances the activity of complement factor H, a crucial regulator of the complement cascade, to better regulate overamplification of the alternative complement cascade.