Open Heart

Long-term incidence and risk factors of atrial fibrillation after percutaneous patent foramen ovale occlusion: a retrospective cohort study

Background Percutaneous patent foramen ovale (PFO) closure is an established intervention for secondary prevention of ...
Open Heart

Development of a heart failure with preserved ejection fraction risk prediction score in primary care settings with a high HIV prevalence

Background Antiretroviral therapy (ART)-treated people with HIV (PWH) have increased risk of heart failure with preserved ...
Open Heart

Ultra-rapid outpatient treatment of patients with severe aortic stenosis presenting with acute valve syndrome: evaluation of a novel pathway for urgent TAVI

Background Up to 30% of patients undergoing transcatheter aortic valve implantation (TAVI) have presented to hospital with ...
Open Heart

Does increasing model complexity improve HEART-based chest pain risk stratification? A multicentre development and held-out emergency department vali…

Background and objectives The History, ECG, Age, Risk factors and Troponin (HEART) score is widely used for emergency ...
Open Heart

Nationwide LDL-C goal attainment in high-risk and very-high-risk patients in Denmark: real-world lipid management and simulated impact of guideline implementation

Aim Low-density lipoprotein cholesterol (LDL-C) goal attainment remains suboptimal among individuals with or at risk for atherosclerotic cardiovascular disease (ASCVD). We evaluated contemporary ...
openheart.bmj

Smokeless tobacco use and circulatory disease risk: a systematic review and meta-analysis

Objective Smokeless tobacco use is a public health issue throughout the world, but reviews and analyses of circulatory disease risks associated with smokeless tobacco use may be outdated or incomplete ...
openheart.bmj

Impella versus IABP in acute myocardial infarction complicated by cardiogenic shock

Objective We investigated the benefit of Impella, a modern percutaneous mechanical support (pMCS) device, versus former standard intra-aortic balloon pump (IABP) in acute myocardial infarction ...
openheart.bmj

Prevalence and incidence of amyloid transthyretin amyloidosis in the USA: insights from claims databases and electronic health records

Background Amyloid transthyretin (ATTR) amyloidosis is a rare, life-threatening disease frequently manifesting with cardiomyopathy (ATTR-CM), polyneuropathy (ATTR-PN) or both (ATTR-mixed). We ...
openheart.bmj

Bleeding after percutaneous coronary intervention: can we still ignore the obvious?

Percutaneous coronary intervention (PCI) is the most common cardiac invasive procedure to treat patients with coronary artery disease. In the USA, it is estimated that more than one million patients ...
openheart.bmj

Incidence of cardiovascular events and gastrointestinal bleeding in patients receiving clopidogrel with and without proton pump inhibitors: an updated meta-analysis

Background Dual antiplatelet therapy is the standard of care after coronary stent placement but increases the bleeding risk. The effects of proton pump inhibitors (PPIs) on clopidogrel metabolism have ...
openheart.bmj

Coronary artery calcium progression after coronary artery bypass grafting surgery

Objectives Accelerated atherosclerosis is a well-established phenomenon after coronary artery bypass grafting surgery (CABG). In this study, we analysed coronary artery calcium (CCS) progression after ...
openheart.bmj

Ivermectin may be a clinically useful anti-inflammatory agent for late-stage COVID-19

Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including ...