The development of cancer is not a process triggered immediately by the emergence of an oncogenic mutation. There is growing ...

Learning more about the mTOR complex and how it works is a stepping stone for others who might look for cancer therapies or ways to help treat diabetes and other diseases. In the world of biology, ...

mTOR signaling has emerged as a critical integrator of neuronal activity and synaptic inputs that in turn affect many cell biological processes, including autophagy, protein synthesis, lipid synthesis ...

The FDA has granted Fast Track designation to BM-3103, a novel topical mTOR inhibitor for epidermolysis bullosa simplex currently in phase 2.

Researchers in the Sloan Kettering Institute have solved the structure of an important signaling molecule in cancer cells. They used a new technology called cryo-EM to visualize the structure in three ...

Sirolimus may be an effective treatment for patients with persistent cutaneous sarcoidosis. In a small clinical trial, 7 of 10 patients treated with sirolimus via oral solution had improvements in ...

Network map of 29 authors with frequency greater than five. Nodes represent authors, and the larger the node, the higher the number of papers. The lines represent collaborations with other authors, ...

The principle that form follows function does not only apply to design and architecture. It also applies to biology. Every organism is a universe that lives thanks to the activities of tens of ...