Clonality of the arterial wall was first suggested in 1973 (ref. 1). Since then, several studies have confirmed the clonal nature of atherosclerotic plaques, and emerging evidence suggests that mutant ...

Most cancers originate from genetic abnormalities, specifically the accumulation of somatic mutations. These mutations accumulate in normal cells in all organs of healthy individuals and are driven by ...

In a study published in Current Biology on August 14, Prof. Miao Wei's team at the Institute of Hydrobiology (IHB) of the Chinese Academy of Sciences and Prof. Zhang Jianzhi's team at the University ...

For decades, the standard explanation for autoimmune diseases like rheumatoid arthritis has rested on two pillars: inherited genes and environmental triggers. Now, a growing body of research points to ...

In this Innovation Spotlight, Peter Campbell, the cofounder and chief scientific officer of Quotient Therapeutics discusses a new somatic genomics platform built to identify these mutations and ...

Two new studies from Karolinska Institutet in Sweden have investigated how mutations that occur in muscles and blood vessels over time can affect aging. The studies, which are published in Nature ...

New research suggests that autoimmune diseases may be driven by DNA mutations in immune cells that remove the natural brakes on the immune system. It reveals a previously hidden role for somatic ...

Somatic mutations long known for driving blood cancers such as myeloid leukemia are turning up inside the brain’s immune cells of people with Alzheimer’s disease, where they appear to rewire ...

Somatic testing analyzes genetic material in specific cells or tissues to identify acquired mutations, revolutionizing oncology by enhancing diagnosis, prognosis, and treatment strategies. This ...

A pivotal study has provided unprecedented insights into the genetic architecture of sweet oranges, highlighting the critical role of somatic mutations in shaping fruit development. By constructing a ...

From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body's typically efficient DNA repair machinery and potentially affecting our health ...

Germ cell tumors (GCTs) are a heterogeneous group of neoplasms that predominantly affect adolescents and young adults. Notably, geographical disparities in GCT incidence exist, with higher rates ...