Many mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA). Patients’ cells contain a mixture of mutant and nonmutant mtDNA (a phenomenon called heteroplasmy). The proportion of ...
Nucleotide mutation is thought to be the ultimate driving force of evolution. The processes that determine mutation rate may be highly complex and incompletely understood. In exonic regions ...
Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster
The proteins encoded by the mitochondrial genome, although key to oxidative metabolism, do not have obvious roles in the replication or transmission of mitochondrial DNA (mtDNA). Conventional ...
High-throughput sequencing is a rapid form of genomic sequencing that has been extensively used during infectious disease outbreaks, both to track and contain the infection and to monitor for future ...
A recent genomic analysis presented in a recent bioRxiv* study demonstrates that the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genome is under two distinct selective forces. To come ...
The second science -- Simple selection -- The genetic and ecological context of selection -- History, chance, and necessity -- The rate of genetic deterioration -- The rate of environmental ...
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