In drug development, systematically characterizing a compound’s mechanism of action (MoA), including not only its direct targets but also effector proteins influencing its pharmacological effects, is ...

Over the past two decades, proteome data production and the efficiency of its analysis have seen an exponential increase, leading to the accumulation of data in the PRIDE (Proteomics Identification ...

Researchers created a DIA-MS atlas of 13,609 proteins across 2,856 samples from fetal, healthy adult, paired non-tumor, and ...

A new single-protein analysis technique gives researchers an unprecedented ability to study proteins called scramblases, ...

Networks of protein fibers play important roles in living cells. To understand the dynamical behavior of these networks, model networks are needed to perform in vitro studies. However, fabrication of ...

Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children’s ...

Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children's ...

With a newly developed method that compares AI-generated protein sequences with naturally occurring ones, function- and structure-regulating amino acids can be determined much more precisely than ...

A University of Texas at Austin-led team has reconstructed the most detailed map to date of the molecular machines that carried out the functions of life in an ancient ancestor that gave rise to all ...

A new study published in the journal Nature Medicine suggests that analysing proteins in blood plasma could help scientists ...

The atlas covers six major neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, vascular dementia, Lewy body dementia, progressive supranuclear palsy and frontotemporal degeneration ...