Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome recognizes branched ubiquitin chains. Their finding reveals a multivalent ...

Researchers at National Taiwan University and Academia Sinica have, for the first time at atomic resolution, unveiled how the ...

Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...

Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts by ...

Targeted protein degradation is a therapeutic strategy that utilizes the cell’s natural machinery to eliminate disease-causing proteins. The field traces its origins to the development of thalidomide ...

For more than two decades, medical providers have treated multiple myeloma (MM) with proteasome inhibitors (PIs). This important drug therapy has helped improve survival rates of people with MM.

When blood cancer in children progresses particularly aggressively, it is often due to a genetic defect: a gene fusion, such ...