Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome ...

Researchers at National Taiwan University and Academia Sinica have, for the first time at atomic resolution, unveiled how the ...

Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...

Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts by ...

A team of researchers from Academia Sinica and National Taiwan University has identified the Drosophila Cul2 substrate ...

For more than two decades, medical providers have treated multiple myeloma (MM) with proteasome inhibitors (PIs). This important drug therapy has helped improve survival rates of people with MM.

When blood cancer in children progresses particularly aggressively, it is often due to a genetic defect: a gene fusion, such ...