Single nucleotide substitutions (SNSs) are the major type of somatic variation in tumors 1,2. Even though the absolute majority of the point mutations are neutral 3, there are many examples of ...
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA). We investigated ...
Beijing Zhongke Journal Publising Co. Ltd. In summary, this work provides aninnovative strategy to ease CRISPR mutant identification and Cas9 transgene elimination using a single selection marker, ...
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