(A) UMAP visualization of the 13,363 chondrocytes from healthy human cartilage. Color represents the chondrocyte subset. (B) UMAP visualization of the expression of representative marker genes for ...

“This study provides novel insights into the pathogenesis of OA and suggests a potential therapeutic target in OA treatment.” The concept of osteoarthritis (OA) as a low-grade inflammatory joint ...

GNSC-001 is an investigational, adeno-associated virus gene therapy expressing an optimized form of IL-1Ra. The Food and Drug Administration (FDA) has granted Fast Track designation to GNSC-001 for ...

An x-ray of a pair of hands showing painful joints The role of micro-RNAs in the pathophysiology of hand osteoarthritis was explored, using data from postmenopausal women. Micro-RNAs may serve as ...

Chondrocytes are specialized cells that are essential for cartilage maintenance and repair, and their dysfunction is central to the development of joint diseases like osteoarthritis (OA). However, the ...

Joint overuse, or mechanical overload, occurs when excessive or repetitive stress damages the structures within a joint. The following can contribute to mechanical overload: Everyday activities like ...

Please provide your email address to receive an email when new articles are posted on . Although osteoarthritis is receiving more attention in both the research and clinical arenas than ever, all that ...

Tricompartmental osteoarthritis causes pain and damage due to the cartilage (cushioning) in a joint breaking down. This form of osteoarthritis occurs when there's damage in the three compartments of ...