Scientists have gotten their first detailed look at the molecular structure of an enzyme that Nature has been using for eons to help silence unwanted genetic messages. A team of researchers with ...
Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off ...
Could yeast and humans be any more different? Going by looks alone, probably not. But peering into our genomes reveals surprising similarities. That's because we share a common ancestor called LECA ...
The first crystal structure of Dicer, an enzyme that initiates RNA interference (RNAi), suggests how it works. RNAi is a process in which short RNA molecules recognize messenger RNAs and mark them for ...
RNase III proteins have central roles in RNA silencing by processing double-stranded (ds)RNA precursors into small RNA duplexes 1. Drosha cleaves a primary precursor of miRNA (pri-miRNA) to release a ...
We measured messenger RNA (mRNA) levels of Dicer and Drosha in specimens of invasive epithelial ovarian cancer from 111 patients, using a quantitative reverse-transcriptase–polymerase-chain-reaction ...
In yeast cells, shown here, the Dicer protein protects DNA (bright blue) by helping to resolve conflicts between transcription and replication. If left unchecked, these conflicts can disrupt both ...
A new study in Nature has mapped, at atomic resolution, how the enzyme DICER slices precursor microRNAs at exactly the right spot, with accuracy down to a single nucleotide. The research, which ...
Activation of a specific part of the Dicer enzyme can change its shape in a way that affects its critical role in proper cell division, with implications for both cancer biology and fertility, ...
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