A two-antibody click-chemistry strategy improves targeted chemotherapy delivery to resistant HER2- and EGFR-positive tumors, ...
One of the biggest ways research has benefited patients is by improving how breast cancer is treated. For example, outcomes for people with HER2-positive breast cancer have improved significantly over ...
Tumor cells often hijack normal physiological processes to support their growth, exploiting proteins that are in charge of essential cell functions. It is therefore important to block the activity of ...
(ADCs) and renewing interest in targeted radioimmunoconjugates highlighted by commercial momentum and patent consolidation from Roche/Genentech, Daiichi Sankyo, Gilead Sciences, AstraZeneca, Pfizer, ...
As ADCs become more prevalent in cancer therapy, oncology nurses play a critical role in recognizing and managing the ocular ...
Water-soluble polymers conjugated to proteins and anticancer drugs are in routine clinical use and clinical development as both single agents and components of combination therapy. This is ...
As antibody-drug conjugates move beyond traditional cytotoxic payloads, researchers are rethinking how to make these powerful cancer therapies more precise, more durable, and safer for patients.
ADCs are a drug platform consisting of an antibody, a cytotoxic payload, and a linker molecule designed to enhance the therapeutic index and minimize toxicity of anticancer agents. Optimal patient ...
Most antibody-drug conjugates in clinical development have been made by attaching drug molecules to available sites in an antibody’s natural structure. Although successful, this approach can lead to ...
Driving Innovation in Discovery and Chemistry, Validating Clinical Proof-of Concept and Streamlining CMC of Conjugates with Novel Payloads and Formats Traditional ADCs have seen significant success in ...
The 3rd Next-Generation Conjugates Summit (Boston | February 26-28, 2024) is the only event dedicated to showcasing conjugate drugs with novel payloads and formats, providing unrivalled access to 30+ ...
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