CRISPR-Cas systems are prokaryotic adaptive immune systems that protect against phages and other invading nucleic acids. The evolutionary arms race between prokaryotes and phages gave rise to phage ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms. The ...

The alternative text for this image may have been generated using AI. The backbone of Cascade consists of six copies of CasC organized in a helical stack. Integral to the spine, the crRNA lies in a ...

Say freeze! Sitting in a cryogenic studio and waiting to be bombarded with electrons, two proteins, both part of a gene editing complex, were poised to be imaged for posterity. And then, as the ...