The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

The sarcoplasmic reticulum (SR) is a specialised organelle in skeletal muscle fibres that plays a pivotal role in regulating calcium dynamics crucial for muscle contraction and relaxation. Acting as ...

Calcium plays a central role in a diverse array of cellular processes including signal transduction, secretion of bioactive molecules, muscle contraction and gene expression. Over fifty years ago, it ...

- Muscle cells, also known as myocytes, are specialized cells designed for contraction and force production. Skeletal Muscle Cells: These cells are long, cylindrical, and have a striated (or striped) ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people.

MHH scientist investigates how pro-inflammatory cytokines interfere with muscle metabolism and actively transform muscles.