DNA-Point Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is a versatile super-resolution technique that relies on the predictable binding kinetics between fluorescent imager strands and ...

The Envelope protein (E) is a structural protein encoded by the genome of SARS-CoV, SARS-CoV-2 and MERS-CoV Coronaviruses. It is poorly present in the virus but highly expressed in the host cell, with ...

To choose the best lead candidates during drug and antibody screening, scientists characterize a molecule’s binding properties, such as kinetics and affinity. Robust assay design reduces experimental ...

BRANFORD, Conn.--(BUSINESS WIRE)--Quantum-Si Incorporated (Nasdaq: QSI) (“Quantum-Si,” “QSI” or the “Company”), a proteomics technology company redefining ...

Rapid mixing accessories designed to conduct stopped flow measurements are utilized to characterize interactions and reactions occurring in solution. Reactants are expelled from syringes, mixed, and ...

Determining and evaluating the affinity of small molecule binding to a therapeutic target is a major component of drug discovery and lead optimization. In a technical note entitled “Label-free ...

Grating-coupled interferometry (GCI) is a surface based, a label-free optical sensing technique used for real-time binding kinetic measurements. 1 Typically, GCI is used to detect binding events ...

Surface plasmon resonance (SPR) has revolutionized the study of the intricate protein interactions that are required for the execution and maintenance of complex biological processes, enabling the ...

Biomolecular interactions are at the core of drug discovery and development. In order to accurately determine a biomolecular interaction’s affinity, binding kinetics and thermodynamic profile, among ...

How can treating neurological disease overcome challenges like the synthesis of small molecule agents that penetrate the blood-brain barrier, in order to sustain target engagement at low drug ...