(September 29, 2005, La Jolla, CA) Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the ...
Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin
Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide ...
This is a preview. Log in through your library . Abstract Although it is generally believed that phosphorylation of the regulatory light chain of myosin is required before smooth muscle can develop ...
In a decades-long effort, researchers have discovered how to tweak the molecular pathways that turn heart muscle motors up or ...
Investigators have demonstrated temperature-sensitive regulation of actomyosin, a critical protein complex involved in neuronal development. By applying optically controlled heating, the team ...
New research sheds light on the interaction between the semi-flexible protein tropomyosin and actin thin filaments. The study, published by Cell Press on February 15th in the Biophysical Journal, ...
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