The San Francisco 49ers, led by quarterback Mac Jones, face the New York Giants, led by quarterback Jaxson Dart, on Sunday, Nov. 2, 2025 at MetLife Stadium in East Rutherford, N.J.

Preview the Week 9 matchup between the San Francisco 49ers and New York Giants with predictions, odds, over/under, spread, betting lines and more.

San Francisco is a 2.5-point favorite in the latest 49ers vs. Giants odds from SportsLine consensus, while the over/under for total points scored is 48.5. The 49ers are -151 money line favorites (risk $151 to win $100),

The San Francisco 49ers face the New York Giants needing a win to rally amid another season threatening to be derailed by injuries. Here's what our NFL coverage team expects.

Ferrell and trade acquisition Keion White will be the new blood on the 49ers defensive line, moves that were made even more necessary with the 49ers’ placing defensive lineman Yetur Gross-Matos on injured reserve, meaning he will miss at least the next four games. The 49ers (5-3) face the Giants (2-6) Sunday at MetLife Stadium. (CBS, 10 a.m.)

The Giants' defensive secondary will have to field some young players this weekend, with most of their starters sidelined by injury.

San Francisco 49ers DC Robert Saleh says rookie QB Jaxson Dart is "uber talented" and feels the New York Giants "hit on this one big time."

Few would have expected the lowly New York Giants to be a matchup of particular importance for the San Francisco 49ers, but the stakes have heightened entering Sunday, columnist Ann Killion writes.