Missing DNA replication step revealed in first image of pre-initiation complex

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
Nature

NFIB facilitates replication licensing by acting as a genome organizer

The chromatin-based rule governing the selection and activation of replication origins in metazoans remains to be investigated. Here we report that NFIB, a member of Nuclear Factor I (NFI) family that ...
Nature

Retraction Note: Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly

The Editors-in-Chief have retracted this article. Concerns were raised regarding figure 5, specifically that blots have been reused between papers in different experimental contexts [1]. The authors ...
Phys.org

Researchers reveal how DNA unzipping machine MCM2-7 complex works, with implications for cancer therapy

A research team led by Dr. Yuanliang Zhai from the School of Biological Sciences, The University of Hong Kong (HKU), and his collaborators from The Hong Kong University of Science and Technology ...
EurekAlert!

HKU biologists and collaborators reveal how DNA unzipping machine works, shedding lights on cancer therapy

A research team led by Dr Yuanliang ZHAI from the School of Biological Sciences, The University of Hong Kong (HKU), and his collaborators from The Hong Kong University of Science and Technology (HKUST ...