Israel and Iran have opened a new chapter in their long history of conflict when Israel launched a major attack with strikes early Friday on Tehran.

President Donald Trump on Sunday issued a stark warning to Iran against retaliating on U.S. targets in the Middle East while also predicting Israel and Iran would “soon” make a deal to end their escalating conflict.

Israel has launched a series of strikes against Iran, targeting the country’s nuclear program and other military infrastructure. Iran has launched its own strikes in retaliation.

Israel targeted Iran’s Defense Ministry headquarters in Tehran and sites it alleged were associated with Iran’s nuclear program, while Iranian missiles evaded Israeli air defenses and slammed into buildings deep inside Israel.

DUBAI, United Arab Emirates (AP) — Israel launched an expanded assault on Iran on Sunday, with direct strikes targeting its energy industry and Defense Ministry headquarters, while Tehran unleashed a fresh barrage of missiles blamed for the deaths of four people and injuries of many others.

Regime change in Iran could be a result of Israel's military attacks on the country, Israeli Prime Minister Benjamin Netanyahu told Fox News on Sunday, saying Israel would do whatever is necessary to remove the "existential threat" posed by Tehran.

The Israeli military struck "over 170 targets" in Iran in three days, the Israel Defense Forces (IDF) said on Sunday.

Prime Minister Benjamin Netanyahu of Israel presented Iran’s sophisticated ballistic missiles as a critical threat to Israel’s survival.

President Donald Trump rejected Israel's proposal to assassinate Iran’s Supreme Leader Ayatollah Ali Khamenei, a U.S. official told NBC News. Vaughn Hillyard reports the latest.