Diddy's fate will be in the hands of 12 jurors who will decide if he committed a series of sex crimes over, even as the feds may have lost one of their top witnesses

A judge said Friday that a pool of 45 prospective jurors will be narrowed to 12 jurors and six alternates on Monday.

The trial should remain on schedule after the defense suggested that the final 12 jurors and six alternates could ask to be excused after spending a weekend contemplating a role in a major celebrity's fate.