Lentiviral vector in gene therapy - Wikipedia
WEBLentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses. Lentiviruses are a family of viruses that are responsible for diseases like AIDS, which infect by inserting DNA into …
Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases
WEBAug 2, 2021 · We review the design and use of lentiviral vectors in gene therapy of monogenic diseases, with a focus on controlling gene expression by transcriptional or post-transcriptional mechanisms in the context of vectors that have already entered a clinical development phase.
Lentiviral vectors in gene therapy: their current status and …
WEBHuman gene therapy clinical trials are currently under way using lentivectors in a wide range of human diseases. The intention of this review is to describe the main scientific steps leading to the engineering of HIV-1 lentiviral vectors, and place them in the context of current human gene therapy.
The Revival of Lentiviral Vectors - Nature
WEBNaldini and Cantore’s goal is to use lentiviral vectors for liver-directed gene therapy of hemophilia, the coagulation disorder.
Viral vector platforms within the gene therapy landscape
WEBFeb 8, 2021 · In this review, we will describe three viral vector platforms that have gained wide use for efficacious gene therapy and regulatory approval. These three strategies are based on Ads, AAVs,...
Clinical use of lentiviral vectors | Leukemia - Nature
WEBMar 22, 2018 · Gene therapy, which involves the delivery of DNA encoding a gene of interest into a cell with the intention of treating a disease, extends the power of molecular biology to potentially...
Recent advances in lentiviral vectors for gene therapy
WEBLentiviral vectors (LVs), derived from human immunodeficiency virus, are powerful tools for modifying the genes of eukaryotic cells such as hematopoietic stem cells and neural cells. With the extensive and in-depth studies on this gene therapy vehicle over the past two decades, LVs have been widely ….
Clinical use of lentiviral vectors - PubMed
WEBJul 18, 2020 · CAR T-cell therapies engineered using lentiviral vectors have demonstrated noteworthy clinical success in patients with B-cell malignancies leading to regulatory approval of the first genetically engineered cellular therapy using lentiviral vectors.
Gene Therapy Applications of Non-Human Lentiviral Vectors
WEBSep 29, 2020 · Recent commercialization of lentiviral vector (LV)-based cell therapies and successful reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases and benefit patients.
Gene Therapy Applications of Non-Human Lentiviral Vectors
WEBSep 29, 2020 · As the field of gene therapy is advancing rapidly, the use of LVs uncovers further challenges and possibilities. Advances in virology and an improved understanding of lentiviral biology will aid in the creation of recombinant viral vector variants suitable for translational applications from a variety of lentiviruses.
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