Viral vector platforms within the gene therapy landscape
WEBFeb 8, 2021 · To review the viral vector-based gene therapy landscape, we focus on these three highly regarded vector platforms and describe mechanisms of action and their roles in treating human disease.
Adeno-associated virus as a delivery vector for gene therapy of …
WEBApr 3, 2024 · Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different...
Viral Vectors in Gene Therapy: Where Do We Stand in 2023?
WEBMar 7, 2023 · Viral vectors have been used for a broad spectrum of gene therapy for both acute and chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor, toxic, suicide and immunostimulatory genes, such as cytokines and chemokines, have been applied.
Unlocking the Pathway Puzzle: How Biopharma Can Navigate the Clinical …
WEBFeb 26, 2024 · Pathways have become a critical strategy for both physicians and payers to streamline treatment decision-making, standardize evidence-based care, improve patient outcomes by minimizing...
Viral-vector therapies at scale: Today’s challenges and future ...
WEBMar 29, 2022 · Viral-vector gene therapies are here to stay. Keeping pace with increasing demand requires consideration of challenges, the potential for standardization, and strategizing for accelerating patient access.
Viral vector-based gene therapies in the clinic - PubMed
WEBOct 20, 2021 · In this review, we highlight the diversity of viral vectors, review approved products, and discuss the current clinical landscape of in vivo viral vector-based gene therapies. We have reviewed 13 approved products and their clinical applications.
Time to Rethink the Role of Clinical Pathways in the Era of …
WEBApr 19, 2021 · Several studies of clinical pathways for NSCLC treatment administered before 2015 have suggested that pathway adherence leads to reduced treatment costs.
Drug delivery systems for RNA therapeutics - Nature
WEBJan 4, 2022 · Introduction. RNA therapies can manipulate gene expression or produce therapeutic proteins, making these drugs suitable for pathologies with established genetic targets, including infectious...
Emerging non-viral vectors for gene delivery | Journal of ...
WEBAug 17, 2023 · This review comprehensively outlines the novel fastest-growing and efficient non-viral gene delivery vectors, which include liposomes and lipid nanoparticles (LNPs), highly branched poly (β-amino ester) (HPAE), single-chain cyclic polymer (SCKP), poly (amidoamine) (PAMAM) dendrimers, and polyethyleneimine (PEI).
Clinical pathways and patient-related outcomes in hospital-based ...
WEBFeb 9, 2021 · Clinical pathways represent a multi-disciplinary approach to translate clinical practice guidelines into practical interventions. The literature from 2010 onward regarding the efficacy of adopting a clinical pathway on patient-related outcomes within the in-hospital setting has not been synthesized yet.
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